Established in 1726, Tubac is the site of the first European settlement in Arizona. A year after the Pima Indian uprising in 1751, a military garrison was established here to protect Spanish settlers, missionaries, and peaceful Native American converts of the nearby Tumacácori Mission. It was from here that Juan Bautista de Anza led 240 colonists across the desert—the expedition resulted in the founding of San Francisco in 1776. In 1860 Tubac was the largest town in Arizona. Today, the quiet little town is a popular art colony. More than 80 shops sell such crafts as carved wooden furniture, hand-thrown pottery, delicately painted tiles, and silkscreen fabrics (many shops are closed Monday). You can also find Mexican pottery and trinkets without having to cross the border. The annual Tubac Festival of the Arts has been held in February for more than 50 years.