Highway 1 runs south–north along the coast, linking the towns of Carmel-by-the-Sea, Monterey, and Santa Cruz; some sections have only two lanes. The freeway, U.S. 101, lies to the east, roughly parallel to Highway 1. The two roads are connected by Highway 68 from Pacific Grove to Salinas; Highway 156 from Castroville to Prunedale; Highway 152 from Watsonville to Gilroy; and Highway 17 from Santa Cruz to San Jose. Traffic near Santa Cruz can crawl to a standstill during commuter hours. In the morning, avoid traveling between 7 and 9; in the afternoon avoid traveling between 4 and 7.

The drive south from San Francisco to Monterey can be made comfortably in three hours or less. The most scenic way is to follow Highway 1 down the coast. An often faster route is Interstate 280 south from San Francisco to Highway 17, north of San Jose, to Highway 1 south.

The drive from the Los Angeles area takes five or six hours. Take U.S. 101 to Salinas and head west on Highway 68. You can also follow Highway 1 up the coast.