Finding lodging in Cape Town can be a nightmare during peak travel season (December–January), as many of the more reasonable accommodations are booked up. It's worth traveling between April and August, if you can, to take advantage of the "secret season" discounts that are sometimes half the high-season rate. Other reduced rates can be scored by booking directly online, checking the "Best Available Rate" at large hotels, or simply asking if any specials or discounts are available. If you arrive in Cape Town without a reservation, head for any branch of the Tourism Office, which has a helpful accommodations desk.

First-time, short-term, or business visitors will want to locate themselves centrally. The historic city center is a vibrant and pedestrian-friendly place by day, but at night can feel a bit deserted and edgy, depending on where you are. Night owls may prefer to stay amid the nonstop action of Long Street or Kloof Street, or at the V&A Waterfront, with its plethora of pedestrian-friendly shopping and dining options (though be aware that locals don’t consider the Waterfront the "real" Cape Town). Boutique hotels and bed-and-breakfasts in Gardens are often within walking distance of attractions and dining but will be quieter and often enjoy lovely views. Options along the Atlantic Seaboard are also close to the action and (mostly) pedestrian-friendly, with the added advantage of sea and sunset views. Staying farther out on the Cape Peninsula, whether the False Bay or Atlantic side, provides the closest thing in Cape Town to a beach-vacation atmosphere despite the cold ocean waters. The Southern Suburbs, especially around Constantia or Tokai, can make a good base from which to explore the area’s wine estates as well as the peninsula, but you'll be dependent on a car for everything, and should plan on 25 to 45 minutes to get into town.

Most international flights arrive in the morning, and return flights depart in the evening. Because most hotels have an 11 am checkout and 2 pm check-in, you may find yourself with a lodging gap on travel days. All hotels will hold your luggage, and most will try to accommodate you (some of the larger hotels have lounges where you can spend the hours before your flight), but in peak season you may need to organize a backup plan. Also note that many small, luxury accommodations either do not permit children or have minimum-age restrictions. It's a good idea to inquire in advance if this will be an issue. Cape Town also follows the global trend of not smoking in public places. All hotels will have no-smoking rooms, and most are entirely smoke-free.