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Several neighborhoods come together here, just north of the Roman forum and Colosseum. They range from the bustling, multicultural Esquilino neighborhood to the super-trendy, yet still traditional, ancient rione of Monti. Most travelers will find themselves passing through at least part of the area, either when they come into the Termini train station or pay a visit to Michelangelo’s Moses at the Church of San Pietro in Vincoli. Head farther south for the evocative Via Appia Antica, dotted with ruins and ancient catacombs.