If you're driving in to the city, take I–91 or I–89 from Vermont, I–87 from New York, and Autoroute 20 (also known as Autoroute Jean-Lesage) from Québec City.
Having a car in Downtown isn’t ideal—garages are expensive and on-street parking can be a hassle. The city has a diligent tow-away and fine system for double-parking or sitting in no-stopping zones during rush hour, and ticket costs are steep. In residential neighborhoods, beware of alternate-side-of-the-street-parking rules and resident-only parking. In winter, street plows are ruthless in dealing with parked cars in their way. If they don't tow them, they'll bury them.