America Tours SRL. Explore Bolivia with one of this company's adventure- or culture-themed tours. Or try one of their multicountry packages that can include Chile, Peru, or Argentina. Av. 16 de Julio, #1490, Office 9, La Paz. 02/237–4204. www.america-ecotours.com. From $750 USD.
Fremen Tours. This operator offers interesting, city-focused tours as well as cross-country packages, such as the five-day Essential Bolivia, and longer ones with themes such as the Andes and Amazonia, and the Genesis of the Andean Culture. Av. 20 de Octubre 2396, 10th fl., La Paz. 02/242–1258. www.andes-amazonia.com. From $620 USD.
Kanoo Tours. An excellent all-around choice, Kanoo Tours can book and organize your entire Bolivia experience with reliable operators at every budget level. Calle Illampu 832, La Paz. 02/246–0003 La Paz. www.kanootours.com. From $130 USD.
Magri Turismo. This company is best known for their rustic cabins on the Isla del Sol, with spectacular views over Titikaka. Calle Capitán Ravelo 2101, La Paz. 02/244–2727. www.magriturismo.com. From $390 USD.
Ruta Verde. Operating out of Santa Cruz, this small, personal agency run by a Dutch-Bolivian couple has quickly built a great reputation as one of the best for personalized, private tours in the region, particularly into the Salar de Uyuni. Calle 21 de Mayo, #318, Santa Cruz. 03/339–6470 Santa Cruz. www.rutaverdebolivia.com. From $445 USD.
Turisbus. Best known for their top-notch bus services between La Paz, Titikaka, and Uyuni, Turisbus also offers an excellent selection of tours throughout the country and great day trips around La Paz. Hotel Rosario, Av. Illampu, #704, La Paz, La Paz. 02/245–1658. www.turisbus.com. From $45 USD.