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Although you can "do" Antwerp in a day, you would do much better with two or three days, allowing time to sample some of the great restaurants and the lively nightlife and to properly explore the rich collections of MAS and other museums. This is a walking city, so take the time to explore side streets and squares. Avoid limiting your visit to a Monday, when the museums are closed, for they are an integral part of the experience. Local markets are at their best (and busiest) on weekends.