Vienna is 300 km (187 miles) east of Salzburg, 200 km (125 miles) north of Graz. Main routes leading into the city are the A1 Westautobahn from Germany, Salzburg, and Linz and the A2 Südautobahn from Graz and points south. Rental cars can be arranged at the airport or in town. Buchbinder is a local firm with particularly favorable rates.

On highways from points south or west or from Vienna's airport, "Zentrum" signs clearly mark the route to the center of Vienna. From there, however, finding your way to your hotel is a challenge, because traffic planners have installed a devious scheme prohibiting through traffic in the city core. Traffic congestion within Vienna is not as bad as in some places, but driving to in-town destinations generally takes longer than does public transportation.